IMPROVED DISSOLUTION CHARACTERISTICS AND SOLUBILITY ENHANCEMENT OF POORLY WATER SOLUBLE DRUG BY NOVEL METHOD USING NATURAL GUM AND WATER SOLUBLE POLYMER
نویسندگان
چکیده
منابع مشابه
Solubility Enhancement of Poorly Water Soluble Drugs by Solid Dispersion
Solid dispersions have been employed to enhance the dissolution rates of poorly water-soluble drugs. Many approaches have been investigated for the preparation of solid dispersions. This paper reports the various solubility enhancement strategies in solid dispersion. The approaches described are fusion (melting), solvent evaporation, lyophilization (freeze drying), melt agglomeration process, e...
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Among all newly discovered chemical entities about 40% drugs are lipophillic and fail to reach market due to their poor water solubility. Drug with poor water solubility cause slow dissolution rates, generally show erratic and incomplete absorption leading to low bioavailability when administered orally. Aqueous solubility of any therapeutically active substance is a key property, as it governs...
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ژورنال
عنوان ژورنال: Journal of Drug Delivery and Therapeutics
سال: 2018
ISSN: 2250-1177
DOI: 10.22270/jddt.v8i2.1667